In any case, Hoffman did synthesise a pure and stable form of acetylsalicylic acid on August 10, , and just two years later, Bayer was producing the drug under the name Aspirin as a powder supplied in glass bottles. Since then, the drug has gone on to achieve unimaginable success, making Bayer's name in the medicines world. Of those who contributed to its creation depending on what story you trust Hoffmann, who also synthesised a stable version of heroine, went on to become head of the pharmaceutical marketing department at Bayer, before retiring in then dying in Article by Tom Meek.
Oxford University Press publishes over prestigious, highly cited, and authoritative medical journals, many in collaboration with some of the Please login to the form below. The German chemist Felix Hoffmann famously synthesized two drugs: aspirin, one of the most widely beneficial drugs ever, and heroin, one of the most harmful of illegal substances. These two drugs represent the efforts of lateth-century chemists to create new substances that could be used as medicines, not just to isolate active ingredients from natural products or to imitate them.
One approach toward this end was to modify known physiologically active substances; another was to perform chemical operations on one or more of the myriad organic compounds created as products or by-products of the synthetic dye industry, which had developed in the 19th century and was particularly strong in Germany.
Hoffmann — was the son of a manufacturer in the town of Ludwigsburg in Swabia, Germany. He first found employment in pharmacies in various cities and towns around Germany and later studied chemistry and pharmacy at the University of Munich, graduating in Recommended by one of his professors, Adolf von Baeyer who would win the Nobel Prize in Chemistry in for his work in synthesizing dyes , Hoffmann joined the newly established pharmaceutical research department at the Bayer Company in Elbersfeld.
In the summer of Hoffmann was adding the acetyl group CH 3 CO to all sorts of molecules, with hopes of improving the strength or decreasing the toxicity of physiologically active substances. After the initial success of heroin, which Bayer omits in telling the official version of this story, Heinrich Dreser did agree to investigate the potential of acetylsalicylic acid. Dreser published the first scientific report on the new drug in , w hich he immediately decided to market under the name aspirin.
The only one who did was Heinrich Dreser, who amassed a fortune from the royalties he collected from the aspirin and heroin trials. Disputes over who was the discoverer aside, the different versions reveal that Dreser was the man behind the most prized medicine and the most feared drug of the 20th century. Click Enter. Login Profile. Es En. Economy Humanities Science Technology. Multimedia OpenMind books Authors.
Scientific Insights. Featured author. Robin Mansell. London School of Economics and Political Science. Ge Junbo, male, was born in Wulian, Shandong province on Nov. He is the member of Chinese Academy of Sciences, professor and doctoral supervisor. He is also the designate chairman of the Cardiovascular Disease Branch of Chinese Medical Association, council member of the Cardiovascular Angiography and Interventions Association, international consultant of the American Heart Association.
In Dec. Ge has been engaged in clinical and scientific research work of cardiovascular disease since , and his research area covers the pathogenesis of coronary heart disease, early diagnosis and treatment plan optimization. Click here to find the press release.
Discipline: Cardiology and Epidemiology. Neurology and Vascular Neurology. We would like to hear from you and have a chat, and maybe feature you on our podcast. Please fill in the form below and we will contact you with further information. The Aspirin Story. The story of Aspirin — a versatile medicine with a long history.
Aspirin in cardiovascular disease prevention In the s Laurence Craven, a general practitioner from California, published his work using aspirin to prevent vascular events. One hundred years of aspirin. The Lancet Elwood P. Aspirin yesterday, aspirin today, aspirin tomorrow: a history of prophylactic aspirin. Acetylsalicylic acid. A Modern Herbal by M Grieve. Miner J. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Clinical pharmacology of platelet cyclooxygenase inhibition.
Circulation ; 72 6 Peto R. Editorial: Aspirin and myocardial infarction. Randomized trial of intravenous streptokinase, oral aspirin, both, or neither among 17, cases of suspected acute myocardial infarction: ISIS Collaborative overview of randomised trials of antiplatelet therapy Prevention of death, myocardial infarction and stroke by prolonged antiplatelet therapy in various categories of patients. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients.
Major reduction in risk of early recurrent stroke by urgent treatment of TIA and minor stroke.
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